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🛑 DISC1 (PROTEİN)
DISC1 (PROTEİN)
(GENOMİK)
- DISC1 (Disrupted in schizophrenia 1) insanlarda DISC1 geni tarafından kodlanan bir proteindir.
- Geniş bir etkileşimli etmenler ile eşgüdüm içinde, DISC1 hücre çoğalması, ayrımlaşması, göçü, nöronal axon ve dendrit büyümesi, mitokondrial aktarım, hücre yarılma ve/ya da kaynaşması, ve hücreler arası tutunma gibi süreçlerin düzenlemesine katılır.
- DISC1 molekülünde düzensiz anlatımın ya da değişmiş protein yapısının bireyleri şizofreni, klinik çöküntü, bipolar rahatsızlık ve daha başka psikiyatrik durumların gelişimine yatkın kıldığı gösterilmiştir. (W)
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📘 The DISC1 Pathway Modulates Expression of Neurodevelopmental, Synaptogenic and Sensory Perception Genes.
The DISC1 Pathway Modulates Expression of Neurodevelopmental, Synaptogenic and Sensory Perception Genes (LINK)
Abstract
Background
Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder. There is evidence for genetic interplay between variants in DISC1 and in biologically interacting loci in psychiatric illness. DISC1 also associates with normal variance in behavioral and brain imaging phenotypes.
Methodology
Here, we analyze public domain datasets and demonstrate correlations between variants in the DISC1 pathway genes and levels of gene expression. Genetic variants of DISC1, NDE1, PDE4B and PDE4D regulate the expression of cytoskeletal, synaptogenic, neurodevelopmental and sensory perception proteins. Interestingly, these regulated genes include existing targets for drug development in depression and psychosis.
Conclusions
Our systematic analysis provides further evidence for the relevance of the DISC1 pathway to major mental illness, identifies additional potential targets for therapeutic intervention and establishes a general strategy to mine public datasets for insights into disease pathways. (LINK)
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Figure 1. Flow chart to demonstrate the analysis performed here
This protocol can be adapted to any chosen gene, pathway and disorder by simply replacing DISC1 with the gene of primary interest. |
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🔎 Network of how 100 of the 528 genes identified with significant differential expression relate to DISC1 and its core interactors. (L)
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| Figure 2. Network of how 100 of the 528 genes identified with significant differential expression relate to DISC1and its core interactors.
Network generated through the use of Ingenuity Pathway Analysis (Ingenuity Systems®, www.ingenuity.com), using the build function and connecting the identified genes to the core DISC1 interactome, only allowing for direct interaction. Relationships are supported by at least 1 reference from the literature, from a textbook, or from canonical information stored in the Ingenuity knowledge base. (LINK) |
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📘 Table 1. Psychiatric drug target genes that display DISC1 pathway mediated differential expression
Table 1. Psychiatric drug target genes that display DISC1 pathway mediated differential expression.
This protocol can be adapted to any chosen gene, pathway and disorder by simply replacing DISC1 with the gene of primary interest. |
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📘 Table 2. Table of significant gene ontology terms
Table 2. Table of significant gene ontology terms that are biologically relevant to the DISC1 pathway or major mental illness.
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